Latest Research

  • Letter |

    Distinct subsets of fibroblasts, which differ in their expression of thymus cell antigen 1 (THY1), are responsible for inflammation and tissue damage in mouse models of arthritis.

    • Adam P. Croft
    • , Joana Campos
    • , Kathrin Jansen
    • , Jason D. Turner
    • , Jennifer Marshall
    • , Moustafa Attar
    • , Loriane Savary
    • , Corinna Wehmeyer
    • , Amy J. Naylor
    • , Samuel Kemble
    • , Jenefa Begum
    • , Kerstin Dürholz
    • , Harris Perlman
    • , Francesca Barone
    • , Helen M. McGettrick
    • , Douglas T. Fearon
    • , Kevin Wei
    • , Soumya Raychaudhuri
    • , Ilya Korsunsky
    • , Michael B. Brenner
    • , Mark Coles
    • , Stephen N. Sansom
    • , Andrew Filer
    •  & Christopher D. Buckley
  • Article |

    Cryo-electron microscopy structures reveal that the DNA-repair factor UV-DDB exposes inaccessible nucleosome lesions for binding by inducing a translational shift in the nucleosome position.

    • Syota Matsumoto
    • , Simone Cavadini
    • , Richard D. Bunker
    • , Ralph S. Grand
    • , Alessandro Potenza
    • , Julius Rabl
    • , Junpei Yamamoto
    • , Andreas D. Schenk
    • , Dirk Schübeler
    • , Shigenori Iwai
    • , Kaoru Sugasawa
    • , Hitoshi Kurumizaka
    •  & Nicolas H. Thomä
  • Article |

    The immunogen RC1 facilitates recognition of the V3-glycan patch on the envelope of HIV-1 and elicits specific serological responses in mice and macaques, making it a possible priming immunogen for sequential vaccination strategies in humans.

    • Amelia Escolano
    • , Harry B. Gristick
    • , Morgan E. Abernathy
    • , Julia Merkenschlager
    • , Rajeev Gautam
    • , Thiago Y. Oliveira
    • , Joy Pai
    • , Anthony P. West Jr
    • , Christopher O. Barnes
    • , Alexander A. Cohen
    • , Haoqing Wang
    • , Jovana Golijanin
    • , Daniel Yost
    • , Jennifer R. Keeffe
    • , Zijun Wang
    • , Peng Zhao
    • , Kai-Hui Yao
    • , Jens Bauer
    • , Lilian Nogueira
    • , Han Gao
    • , Alisa V. Voll
    • , David C. Montefiori
    • , Michael S. Seaman
    • , Anna Gazumyan
    • , Murillo Silva
    • , Andrew T. McGuire
    • , Leonidas Stamatatos
    • , Darrell J. Irvine
    • , Lance Wells
    • , Malcolm A. Martin
    • , Pamela J. Bjorkman
    •  & Michel C. Nussenzweig
  • Letter |

    Unstructured light controls the elastic monopole moments of nematic liquid-crystal colloidal particles and switches them to quadrupoles, with like-charged monopoles attracting and oppositely charged ones repelling, enabling reconfigurable dynamic self-assembly.

    • Ye Yuan
    • , Qingkun Liu
    • , Bohdan Senyuk
    •  & Ivan I. Smalyukh
  • Letter |

    Tactile patterns obtained from a scalable sensor-embedded glove and deep convolutional neural networks help to explain how the human hand can identify and grasp individual objects and estimate their weights.

    • Subramanian Sundaram
    • , Petr Kellnhofer
    • , Yunzhu Li
    • , Jun-Yan Zhu
    • , Antonio Torralba
    •  & Wojciech Matusik
  • Letter |

    Two-photon calcium imaging of a large population of dopamine neurons in the ventral tegmental area of mice performing a virtual-reality navigation task reveals the organization principles of the dopamine system.

    • Ben Engelhard
    • , Joel Finkelstein
    • , Julia Cox
    • , Weston Fleming
    • , Hee Jae Jang
    • , Sharon Ornelas
    • , Sue Ann Koay
    • , Stephan Y. Thiberge
    • , Nathaniel D. Daw
    • , David W. Tank
    •  & Ilana B. Witten
  • Article |

    Cryo-electron microscopy and mutation experiments demonstrate that the inactive SHMT2 dimer—and not the pyridoxal-5′-phosphate-bound tetramer—binds to BRISC, which reveals a mechanism for the regulation of deubiquitylases and inflammatory signalling.

    • Miriam Walden
    • , Lei Tian
    • , Rebecca L. Ross
    • , Upasana M. Sykora
    • , Dominic P. Byrne
    • , Emma L. Hesketh
    • , Safi K. Masandi
    • , Joel Cassel
    • , Rachel George
    • , James R. Ault
    • , Farid El Oualid
    • , Krzysztof Pawłowski
    • , Joseph M. Salvino
    • , Patrick A. Eyers
    • , Neil A. Ranson
    • , Francesco Del Galdo
    • , Roger A. Greenberg
    •  & Elton Zeqiraj

Latest Reviews & Analysis

  • News & Views |

    Fibroblast cells promote the development of rheumatoid arthritis. The finding that two distinct fibroblast populations affect different aspects of the disease in mice has implications for efforts to develop clinical treatments.

    • Thomas A. Wynn
  • News & Views |

    It is extremely difficult to observe the radiation that is thought to be emitted by black holes. The properties of this radiation have now been analysed using an analogue black hole comprising a system of ultracold atoms.

    • Silke Weinfurtner
  • Perspective | | open

    Over ten years, the Human Microbiome Project has provided resources for studying the microbiome and its relationship to disease; this Perspective summarizes the key achievements and findings of the project and its relationship to the broader field.

    • Lita M. Proctor
    • , Heather H. Creasy
    • , Jennifer M. Fettweis
    • , Jason Lloyd-Price
    • , Anup Mahurkar
    • , Wenyu Zhou
    • , Gregory A. Buck
    • , Michael P. Snyder
    • , Jerome F. Strauss III
    • , George M. Weinstock
    • , Owen White
    •  & Curtis Huttenhower
  • News & Views |

    One type of CRISPR–Cas bacterial-defence system destroys phage and bacterial RNA, which leads to bacterial dormancy. Dormancy is found to limit viral spread, and also protects against unrelated viruses and viral mutants.

    • Simon A. Jackson
    •  & Peter C. Fineran
  • News & Views |

    Object manipulation using an innovative glove allows large databases of detailed pressure maps to be obtained. Such data could lead to advances in robotic sensing and in our understanding of the role of touch in manipulation.

    • Giulia Pasquale
  • News & Views |

    The Human Microbiome Project put the health-associated microbes found in humans on centre stage. The project’s second phase shows how microbial disturbance in disease is linked to host processes.

    • Verónica Lloréns-Rico
    •  & Jeroen Raes

News & Comment

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Some of the most effective new pharmaceutical drugs are highly complex biological molecules.

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